PRPP SYNTHETASE SUPERACTIVITY IN LYMPHOBLAST LINES: 11

Selective expression of phosphoribosylpyrophosphate synthetase superactivity in human lymphoblast lines.

Phenotypic expression of 5-phosphoribosyl 1-pyrophosphate (PRPP) synthetase superactivity was examined in lymphoblast lines derived from six unrelated male patients. Fibroblasts from these individuals have increased rates of PRPP and purine nucleotide synthesis and express four classes of kinetic derangement underlying enzyme superactivity: increased maximal reaction velocity (catalytic defect)...

Phosphoribosylpyrophosphate synthetase superactivity

Feedback-Resistant Phosphoribosylpyrophosphate Synthetase Associated with Purine Overproduction and Gout PHOSPHORIBOSYLPYROPHOSPHATE AND PURINE METABOLISM

other family members investigated. The fibroblast studA preliminary report was presented at the Annual Meeting of the Israeli Association of Chemical Pathology, Rehovot, Israel, March 1974. Professor de Vries is an Established Investigator of the Chief Scientist's Bureau, Ministry of Health. Received for publication 6 February 1975 and in revised form 7 July 1975. ies demonstrate the following ...

Feedback-Resistant Phosphoribosylpyrophosphate Synthetase Associated with Purine Overproduction and Gout PHOSPHORIBOSYLPYROPHOSPHATE AND PURINE METABOLISM

other family members investigated. The fibroblast studA preliminary report was presented at the Annual Meeting of the Israeli Association of Chemical Pathology, Rehovot, Israel, March 1974. Professor de Vries is an Established Investigator of the Chief Scientist's Bureau, Ministry of Health. Received for publication 6 February 1975 and in revised form 7 July 1975. ies demonstrate the following ...

Substitutions in hamster CAD carbamoyl-phosphate synthetase alter allosteric response to 5-phosphoribosyl-alpha-pyrophosphate (PRPP) and UTP.

CPSase (carbamoyl-phosphate synthetase II), a component of CAD protein (multienzymic protein with CPSase, aspartate transcarbamylase and dihydro-orotase activities), catalyses the regulated steps in the de novo synthesis of pyrimidines. Unlike the orthologous Escherichia coli enzyme that is regulated by UMP, inosine monophosphate and ornithine, the mammalian CPSase is allosterically inhibited b...